Short Communication

Protective effect of clenbuterol on duodenal epithelium during food restriction in rats

L.A. Cardoso, M.L. Ferreira
Journal of the South African Veterinary Association | Vol 73, No 2 | a560 | DOI: https://doi.org/10.4102/jsava.v73i2.560 | © 2002 L.A. Cardoso, M.L. Ferreira | This work is licensed under CC Attribution 4.0
Submitted: 06 July 2002 | Published: 06 July 2002

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L.A. Cardoso,
M.L. Ferreira,

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Abstract

The aim of the study was to examine the effect of the 2-adrenoceptor, clenbuterol, on the duodenal epithelium of food-restricted rats. Clenbuterol was administered as a dietary admixture (4 mg/kg diet) to three groups of male Wistar rats (n =8) housed individually in metabolic cages and fed ad libitum for 15 days at 110 %and 160 %of the estimated requirement for energy maintenance. Untreated groups at each energy intake level were also included. Samples of the duodenum were examined by light microscopy. Compared with control animals, clenbuterol treatment significantly increased body mass in all diet groups, although it induced no changes in mean food intake. Gastrointestinal (GIT) dry mass was increased by clenbuterol only in the most severely-restricted-diet group. In this group, clenbuterol treatment increased GIT tissue nitrogen (23 %), more than it did in the ad libitum group (13 %). In all treated groups, clenbuterol induced significant hypertrophy of duodenal enterocytes and circular muscle layers, and the diameter of lymphatic vessels increased. In the clenbuterol-treated, restricted-diet groups the height of the brush borders of enterocytes increased. It is concluded that clenbuterol has a protective effect on the intestinal structure in rats on restricted as well as ad libitum diets.

Keywords

Adrenergic Agonists; Food Restriction; Intestinal Epithelium

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