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Non-steroidal anti-flammatory drugs in domestic animals: I. Their classification, mechanism of action and pharmacological effects

G. E. Swan
Journal of the South African Veterinary Association | Vol 62, No 1 | a1584 | DOI: https://doi.org/10.4102/jsava.v62i1.1584 | © 2020 G. E. Swan | This work is licensed under CC Attribution 4.0
Submitted: 31 August 2017 | Published: 30 March 1991

About the author(s)

G. E. Swan, Department of Pharmacology and Toxicology, Faculty of Veterinary Science, University of Pretoria, South Africa

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Abstract

A large number of non-steroidal anti-inflammatory drugs, of different chemical groups are available for veterinary use. These drugs act mainly by inhibiting the. formation of endoperoxides (prostaglandins and thromboxanes) through the inhibition of cyclo-oxygenase in the eicosanoid pathway. A wide range of pharmacological effects, including analgesic, antipyretic and anti-inflammatory effects occur as a result of this inhibition. The classification, mechanism of action and pharmacological effects of these drugs are reviewed.

Keywords

Non-steroidal anti-flammatory drugs; review; classification; pharmacology; domestic animals

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