Original Research

An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy

B. Nevill, A. Leisewitz, A. Goddard, P. Thompson
Journal of the South African Veterinary Association | Vol 81, No 1 | a90 | DOI: https://doi.org/10.4102/jsava.v81i1.90 | © 2010 B. Nevill, A. Leisewitz, A. Goddard, P. Thompson | This work is licensed under CC Attribution 4.0
Submitted: 03 May 2010 | Published: 03 May 2010

About the author(s)

B. Nevill,
A. Leisewitz,
A. Goddard,
P. Thompson,

Full Text:

PDF (232KB)

Abstract

The extent of trauma in a patient can be difficult for a clinician to quantify. A prospective study was performed on 2 groups of dogs undergoing either ovariohysterectomy or hemilaminectomy. The serum activity of creatine kinase and serum concentration of C-reactive protein were evaluated preoperatively and then at 4, 6, 8, 12, 24 and 48 hours postoperatively in both groups. The results were compared statistically both within and between the 2 groups. A wide range of results was found at each time point for both analytes although there were no significant differences for either analyte between the 2 surgical groups preoperatively. Thereafter there were significant differences in creatine kinase activity levels between the 2 groups. C-reactive protein concentration results were very similar in the 2 groups with no statistical difference at any time point. The results of this study suggest that the evaluation of CK and CRP at any one time point in a traumatised animal is of limited value. However, the evaluation of the trend of these 2 analytes, even over a relatively short time period, may allow for useful prognostication in clinical cases.

Keywords

No related keywords in the metadata.

Metrics

Total abstract views: 3110
Total article views: 2567

 

Crossref Citations

1. Kinetics of Plasma Cell‐Free DNA and Creatine Kinase in a Canine Model of Tissue Injury
I.J. Wilson, R.K. Burchell, A.J. Worth, S.E. Burton, K.R. Gedye, K.J. Clark, K.R. Crosse, M. Jack, T.F. Odom, S.J. De Grey, K.M.S. McGlade, S.C. Tomlin, N. Lopez‐Villalobos, A. Gal
Journal of Veterinary Internal Medicine  vol: 32  issue: 1  first page: 157  year: 2018  
doi: 10.1111/jvim.14901