Original Research

The effect of endotoxin and anti-endotoxin serum on synovial fluid parameters in the horse

R.D. Gottschalk, F. Reyers, S.S. Van den Berg
Journal of the South African Veterinary Association | Vol 69, No 1 | a801 | DOI: https://doi.org/10.4102/jsava.v69i1.801 | © 1998 R.D. Gottschalk, F. Reyers, S.S. Van den Berg | This work is licensed under CC Attribution 4.0
Submitted: 12 July 1998 | Published: 12 July 1998

About the author(s)

R.D. Gottschalk,
F. Reyers,
S.S. Van den Berg,

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Abstract

The effects of a commercially available equine hyperimmune anti-endotoxin serum on synovial fluid parameters were evaluated in an induced synovitis model in normal horses. Four groups of 3 horses each received lipopolysaccharide (LPS) plus hyperimmune antiendotoxin (anti-LPS), LPS, anti-LPS, and Ringers lactate (control) respectively injected into the left intercarpal joint. Synovial fluid parameters were measured at 4, 8, 24 and 72 h. It was found that anti-LPS had no attenuating effect on the LPS and that it induced a synovitis almost equivalent to that induced by LPS alone. The introduction of sterile Ringers lactate solution into the carpal joint together with repeated aseptic arthrocentesis induces a mild inflammatory response.

Keywords

Endotoxin; Horses; Hyperimmune Anti-Endotoxin; Synovitis

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