Original Research

The effect of an angiotensin-converting enzyme inhibitor on water and electrolyte balance in water-restricted sheep

R.A. Meintjies, H. Engelbrecht
Journal of the South African Veterinary Association | Vol 70, No 4 | a783 | DOI: https://doi.org/10.4102/jsava.v70i4.783 | © 1999 R.A. Meintjies, H. Engelbrecht | This work is licensed under CC Attribution 4.0
Submitted: 12 July 1999 | Published: 12 July 1999

About the author(s)

R.A. Meintjies,
H. Engelbrecht,

Full Text:

PDF (130KB)

Abstract

The importance of angiotensin II in the regulation of water and electrolyte balance in sheep is questionable. In this trial the effects of an angiotensin-converting enzyme (ACE) inhibitor were quantified in sheep on restricted water intake. Comparing the phase of water restriction only with that of water restriction plus ACE inhibition, significant increases were observed during the latter phase in urine volume, sodium and potassium excretion via the urine, sodium concentration in the plasma and osmolar clearance. Urine osmolarity decreased with inhibition of angiotensin II formation while variables such as water, sodium and potassium loss via the faeces were unaffected. Most of the renal effects of ACE inhibition, except the increase in urinary potassium excretion, were explicable in terms of the established functions of angiotensin II. Furthermore, results of this trial indicate that angiotensin II has no significant effect on the intestine in regulating water and electrolyte excretion via the faeces.

Keywords

Angiotensin-Converting Enzyme Inhibition; Angiotensin II; Colon; Potassium; Renal Function; Sheep; Sodium; Water

Metrics

Total abstract views: 2572
Total article views: 2455

 

Crossref Citations

1. 17β-Estradiol deficiency reduces potassium excretion in an angiotensin type 1 receptor-dependent manner
Hong Ji, Wei Zheng, Celine Falconetti, Darren M. Roesch, Susan E. Mulroney, Kathryn Sandberg
American Journal of Physiology-Heart and Circulatory Physiology  vol: 293  issue: 1  first page: H17  year: 2007  
doi: 10.1152/ajpheart.00950.2006