Original Research
Clinical, cardiopulmonary and haemocytological effects of xylazine in goats after acute exposure to different environmental temperature and humidity conditions
Journal of the South African Veterinary Association | Vol 71, No 3 | a705 |
DOI: https://doi.org/10.4102/jsava.v71i3.705
| © 2000 E.G.M. Mogoa, G.F. Stegmann, A.J. Guthrie, G.E. Swan
| This work is licensed under CC Attribution 4.0
Submitted: 10 July 2000 | Published: 10 July 2000
Submitted: 10 July 2000 | Published: 10 July 2000
About the author(s)
E.G.M. Mogoa,G.F. Stegmann,
A.J. Guthrie,
G.E. Swan,
Full Text:
PDF (67KB)Abstract
This study was carried out to assess the influence of xylazine administration on clinical, cardiopulmonary and haemocytological variables after acute exposure to different environmental conditions. Xylazine hydrochloride was administered intravenously at 0.1 mg/kg body mass to 6 clinically healthy, castrated male goats. All animals were exposed for 60 min to 3 sets of climatic conditions: 14 °C, 33% relative humidity; 24 °C, 55% RH, and 34 °C, 65% RH. The variables that were measured for a period of 60 min after xylazine administration were sedation, analgesia, salivation, urination, ventilation rate, heart-rate, mean arterial blood pressure, oesophageal temperature, haematocrit, mean corpuscular volume and mean corpuscular haemoglobin concentration. Xylazine induced sedation, analgesia, salivation and urination independently of the 3 environmental conditions. Environment had no influence on the onset, duration and recovery from sedation. In the 14 °C environment, xylazine resulted in a significant decrease in ventilation and heart-rate from baseline values. Significant changes in mean arterial blood pressure, haemoglobin concentration, mean corpuscular volume, haematocrit and red cell count were observed in the 3 environments. Total plasma protein was significantly altered at 24 °C and 34 °C. Acute exposure of goats to different environmental conditions had no significant influence on the clinical, cardiopulmonary and haemocytological variables. Physiological changes induced by xylazine were therefore independent of the environment.
Keywords
Caprine; Cardiopulmonary; Haematology; Sedation; Temperature; Xylazine
Metrics
Total abstract views: 2463Total article views: 2424
Crossref Citations
1. Intrathecal adenosine enhances the antinociception of Xylazine in goats
Mahmoud M. Abouelfetouh, Eman Salah, Lingling Liu, Mingxing Ding, Yi Ding
BMC Veterinary Research vol: 18 issue: 1 year: 2022
doi: 10.1186/s12917-022-03193-9