Original Research

A krimpsiekte-like syndrome in small stock poisoned by Ornithogalum toxicarium Archer & Archer

C.J. Botha, R.A. Schultz, J.J. Van der Lugt, C. Archer
Journal of the South African Veterinary Association | Vol 71, No 1 | a668 | DOI: https://doi.org/10.4102/jsava.v71i1.668 | © 2000 C.J. Botha, R.A. Schultz, J.J. Van der Lugt, C. Archer | This work is licensed under CC Attribution 4.0
Submitted: 09 July 2000 | Published: 10 July 2000

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C.J. Botha,
R.A. Schultz,
J.J. Van der Lugt,
C. Archer,

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Krimpsiekte (the syndrome associated with chronic cardiac glycoside poisoning) was purportedly induced by Ornithogalum toxicarium in the Karas mountains area of Keetmanshoop, Namibia. This chinkerinchee species was previously linked to a condition known as 'kwylbek' krimpsiekte in small stock in the Beaufort West district of the Western Cape Province, South Africa. In a dosing trial, respiratory distress, tachycardia and sternal recumbency were observed in 2 sheep drenched with fresh plant material. A fluorescence polarisation immunoassay (FPIA) detected the presence of a substance that cross-reacted with digoxin antibodies in some of the plant material collected at Keetmanshoop and Beaufort West. This is the first time that apparent cardiac glycoside poisoning was induced by a southern African chinkerinchee species. The presence of the cardiac glycoside-like substance in O. toxicarium requires further chemical verification.


Cardiac Glycoside Poisoning; Chinkerinchee; Goats; Krimpsiekte; Ornithogalum; Sheep


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