Original Research

Toxicokinetics of cotyledoside following intravenous administration to sheep

C.J. Botha, T. Rundberget, G.E. Swan, M.S.G. Mulders, A. Flaoyen
Journal of the South African Veterinary Association | Vol 74, No 1 | a488 | DOI: https://doi.org/10.4102/jsava.v74i1.488 | © 2003 C.J. Botha, T. Rundberget, G.E. Swan, M.S.G. Mulders, A. Flaoyen | This work is licensed under CC Attribution 4.0
Submitted: 25 June 2003 | Published: 25 June 2003

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C.J. Botha,
T. Rundberget,
G.E. Swan,
M.S.G. Mulders,
A. Flaoyen,

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Cotyledoside, a bufadienolide cardiac glycoside, was administered intravenously to sheep in 2 studies. In experiment 1, sheep (n = 4) received 0.0135 mg / kg daily on 5 consecutive days and in the 2nd experiment, sheep (n = 4) received 0.027 mg / kg as a single dose. Jugular blood was collected at different time intervals and kinetic parameters were determined. The data fitted a 1-compartmental model. In both experiments a short half-life (t1/2) and mean residence time (MRT), a relative small volume of distribution (Vdss) and rapid clearance were calculated. In the 1st experiment, t1/2 and MRT increased significantly (P < 0.007) from Day (D) 0 to D 4. It is suggested that the rapid decline in plasma cotyledoside concentrations in sheep denotes rapid distribution of cotyledoside to the tissues or extracellular spaces and possible accumulation at the biophase.


Cardiac Glycoside; Cotyledoside; Kinetics; Krimpsiekte; Sheep


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