Short Communication

Evaluation of hydroxypropyl-b-cyclodextrin in the treatment of aldicarb poisoning in rats : short communication

R.S. Verster, C.J. Botha
Journal of the South African Veterinary Association | Vol 75, No 4 | a480 | DOI: https://doi.org/10.4102/jsava.v75i4.480 | © 2004 R.S. Verster, C.J. Botha | This work is licensed under CC Attribution 4.0
Submitted: 21 June 2004 | Published: 21 June 2004

About the author(s)

R.S. Verster,
C.J. Botha,

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Abstract

Cyclodextrins are ring-shaped oligosaccharides with a hydrophilic exterior and a hydrophobic interior. The interior cavity is capable of complexing fat-soluble molecules small enough to fit inside. Sprague-Dawley rats were used to evaluate the efficacy of hydroxypropyl-b-cyclodextrin as treatment of aldicarb poisoning in rats. Survival times in the majority of rats dosed with aldicarb and receiving intravenous cyclodextrin were longer compared with the control rats only dosed with aldicarb per os.

Keywords

Aldicarb; Cyclodextrin; Poisoning; Rats

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