Original Research
The pharmacokinetics of diminazene aceturate after intramuscular administration in healthy dogs
Journal of the South African Veterinary Association | Vol 76, No 3 | a416 |
DOI: https://doi.org/10.4102/jsava.v76i3.416
| © 2005 D.M. Miller, G.E. Swan, R.G. Lobetti, L.S. Jacobson
| This work is licensed under CC Attribution 4.0
Submitted: 14 June 2005 | Published: 14 June 2005
Submitted: 14 June 2005 | Published: 14 June 2005
About the author(s)
D.M. Miller,G.E. Swan,
R.G. Lobetti,
L.S. Jacobson,
Full Text:
PDF (181KB)Abstract
The pharmacokinetics of diminazene aceturate following intramuscular (i.m.) administration at 4.2 mg/kg was evaluated in 8 healthy German Shepherd dogs. Blood samples were collected at 19 intervals over a period of 21 days. Diminazene plasma concentrations were measured using a validated HPLC method with UV detection and a sensitivity of 25 ng/m . The in vitro and in vivo binding of diminazene to blood elements was additionally determined. Diminazene pharmacokinetics showed a large inter-individual variation after i.m. administration. It had a short absorption half-life (K01-HL of 0.11 + 0.18 h), resulting in a Cmax of 1849 + 268.7 ng/mℓ at Tmax of 0.37 h and a mean overall elimination half-life (T1/2ß) of 5.31 + 3.89 h. A terminal half-life of 27.5 + 25.0 h was measured. At 1 h after i.m. injection, 75% of the diminazene in whole blood was in the plasma fraction. The results of this study indicate that diminazene is rapidly distributed and sequestered into the liver, followed by a slower terminal phase during which diminazene is both redistributed to the peripheral tissues and/or renally excreted. It is recommended that diminazene administered i.m. at 4.2 mg/kg should not be repeated within a 21-day period.
Keywords
Babesia Canis; Babesiosis; Berenil; Canine; Diminazene; Liver Sequestration; Pharmacokinetics; Pharmacology
Metrics
Total abstract views: 3419Total article views: 6003
Crossref Citations
1. Babesiosis: Current status and future perspectives in Pakistan and chemotherapy used in livestock and pet animals
Muhammad Azhar, Javaid Ali Gadahi, Bachal Bhutto, Sambreena Tunio, Waseem Ali Vistro, Haleema Tunio, Sahar Bhutto, Teerath Ram
Heliyon vol: 9 issue: 6 first page: e17172 year: 2023
doi: 10.1016/j.heliyon.2023.e17172