Case Report

Immunohistochemical study of a canine neurofibroma

Hamidreza Fattahian, Pejman Mortazavi, Hamidreza Moosavian, Hamid Mohyeddin, Roozbeh Moridpour
Journal of the South African Veterinary Association | Vol 83, No 1 | a18 | DOI: https://doi.org/10.4102/jsava.v83i1.18 | © 2012 Hamidreza Fattahian, Pejman Mortazavi, Hamidreza Moosavian, Hamid Mohyeddin, Roozbeh Moridpour | This work is licensed under CC Attribution 4.0
Submitted: 29 March 2012 | Published: 07 August 2012

About the author(s)

Hamidreza Fattahian, Department of Surgery, Science and Research Branch, Islamic Azad University, Iran, Islamic Republic of
Pejman Mortazavi, Department of Pathology, Science and Research Branch, Islamic Azad University, Iran, Islamic Republic of
Hamidreza Moosavian, Department of Clinical Sciences, University of Tehran, Iran, Islamic Republic of
Hamid Mohyeddin, Department of Clinical Sciences, Garmsar Branch, Islamic Azad University, Iran, Islamic Republic of
Roozbeh Moridpour, Department of Surgery, Science and Research Branch, Islamic Azad University, Iran, Islamic Republic of

Abstract

Accurate diagnostic approaches to differentiate peripheral nerve sheet tumours from others have not been firmly established. The aim of this case report was to diagnose neurofibroma using a combination of diagnostic imaging, histopathology and immunohistochemistry, which were applied to a canine neurofibroma arising in the left mandible. The tumour was surgically excised and examined histologically. Round or spindle cells, with elongated, dense and homogenous chromatin and pale cytoplasm typical of Schwann cells in an abundant fibromyxomatous stroma, with ruby collagen fibres were seen. Immunohistochemistry demonstrated that S-100 and vimentin were more than 70% positive. Neurofibroma may therefore be recognisable using markers such as S-100 and vimentin.

Keywords

dog; immunohistochemistry; neurofibroma; S-100; vimentin

Metrics

Total abstract views: 4931
Total article views: 14231

 

Crossref Citations

1. Sudden death due to rupture of the right internal carotid artery in neurofibromatosis type 1: A case report
Yue Liang, Fang Tong, Lin Zhang, Wenhe Li, Yiwu Zhou
Legal Medicine  vol: 21  first page: 33  year: 2016  
doi: 10.1016/j.legalmed.2016.05.004

2. Retraction Note: Ulnar malignant peripheral nerve sheath tumour diagnosis in a mixed-breed dog as a model to study human: histologic, immunohistochemical, and clinicopathologic study
Abbas Tavasoly, Javad Javanbakht, Fariba Khaki, Ehsan Hosseini, Alimohammad Bahrami, Mehdi Aghamohammad Hassan, Mohammadmehdi Mirabad
Diagnostic Pathology  vol: 11  issue: 1  year: 2016  
doi: 10.1186/s13000-016-0570-7

3. Neurofibroma of the ulnar nerve in the carpal canal in a dog: treatment by marginal neurectomy
R. M. Basa, A. M. Crowley, K. A. Johnson
Journal of Small Animal Practice  vol: 61  issue: 8  first page: 512  year: 2020  
doi: 10.1111/jsap.12945