Original Research

The effect of endogenously produced carbon monoxide on the oxygen status of dogs infected with Babesia canis

J. H. Taylor, A. J. Gutherie, A. Leisewitz
Journal of the South African Veterinary Association | Vol 62, No 4 | a1774 | DOI: https://doi.org/10.4102/jsava.v62i4.1774 | © 2020 J. H. Taylor, A. J. Gutherie, A. Leisewitz | This work is licensed under CC Attribution 4.0
Submitted: 27 November 2018 | Published: 31 December 1991

About the author(s)

J. H. Taylor, Department of Physiology, Faculty of Veterinary Science, University of Pretoria, South Africa
A. J. Gutherie, Equine Research Centre, University of Pretoria, South Africa
A. Leisewitz, Department of Medicine, University of Pretoria, South Africa

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Abstract

Carboxyhaemoglobin fractions were found to be significantly higher (p<0,05) in dogs (n=5) with severe babesiosis than in control subjects (n=5). The enzymatic conversion of haem to biliverdin by haem oxygenase is the only known source of endogenous carbon monoxide. We propose that the increased production of endogenous carbon monoxide following the haemolysis associated with babesiosis, results in the carboxyhaemoglobinaeroia observed in this study. The superimposition of carboxyhaemoglobinaemia on severe anaemia results in further compromise of the oxygen status of dogs with severe babesiosis, and probably plays a role in the pathogenesis of the hypoxic tissue damage associated with this condition.

Keywords

Canine; babesiosis; Babesia canis; carbon monoxide; carboxyhaemoglobin

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