Original Research

Effect of percutaneous transthoracic lung biopsy on oxidative metabolism in sheep

Andreza A. Silva, Danilo O.L. Ferreira, Bianca P. Santarosa, Adriano Dias, Débora C. Damasceno, Roberto C. Gonçalves
Journal of the South African Veterinary Association | Vol 83, No 1 | a14 | DOI: https://doi.org/10.4102/jsava.v83i1.14 | © 2012 Andreza A. Silva, Danilo O.L. Ferreira, Bianca P. Santarosa, Adriano Dias, Débora C. Damasceno, Roberto C. Gonçalves | This work is licensed under CC Attribution 4.0
Submitted: 16 March 2012 | Published: 01 June 2012

About the author(s)

Andreza A. Silva, Department of Veterinary Clinics, São Paulo State University, Brazil
Danilo O.L. Ferreira, Department of Veterinary Clinics, São Paulo State University, Brazil
Bianca P. Santarosa, Department of Veterinary Clinics, São Paulo State University, Brazil
Adriano Dias, Research Support Center, São Paulo State University, Brazil
Débora C. Damasceno, Department of Gynaecology and Obstetrics, São Paulo State University, Brazil
Roberto C. Gonçalves, Department of Veterinary Clinics, São Paulo State University, Brazil

Abstract

This study aimed to assess the effect of percutaneous transthoracic lung biopsy on the oxidative metabolism of sheep by measuring the oxidative stress markers of superoxide dismutase (SOD), total glutathione (GSH-t), peroxidase (GSH-Px) and thiobarbituric acid reactive substances (TBARS) in the red cells of these animals. Blood samples were collected from 20 clinically healthy sheep prior to, and 30 min after, percutaneous transthoracic lung biopsy. After biopsy, there was a significant decrease (p < 0.05) in SOD and GSH-Px activity, with no significant change (p ≥ 0.05) in GSH-t and TBARS concentrations. These results showed that percutaneous transthoracic lung biopsy did not significantly affect the oxidative metabolism of sheep 30 min after the procedure, which may be used widely in this species without causing serious tissue damage.

 


Keywords

glutathione; lung biopsy; oxidative stress; reactive oxygen species; sheep

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Crossref Citations

1. The diagnostic accuracy of oxidative stress biomarkers in sheep with pneumonic pasteurellosis
Wael M. El-Deeb, Ahmed Elmoslemany
Comparative Clinical Pathology  vol: 26  issue: 2  first page: 363  year: 2017  
doi: 10.1007/s00580-016-2382-2