Historical Article

Krimpsiekte in South Africa: Historical perspectives

Christo J. Botha
Journal of the South African Veterinary Association | Vol 84, No 1 | a1059 | DOI: https://doi.org/10.4102/jsava.v84i1.1059 | © 2013 Christo J. Botha | This work is licensed under CC Attribution 4.0
Submitted: 24 May 2013 | Published: 18 November 2013

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Christo J. Botha, Department of Paraclinical Sciences, University of Pretoria, South Africa

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Krimpsiekte, also known as cotyledonosis or nentain sheep and goats, has been recognised as a disease entity since 1775. However, it was only in 1891 that Veterinary Surgeon Soga reproduced the condition by dosing Cotyledon (= Tylecodon) ventricosus leaves to goats. Professor MacOwan, a botanist, confirmed the identity of these nenta plants. From a South African veterinary toxicological point of view the date 1891 is of considerable historical significance as this was the first time that a plant was experimentally demonstrated to be toxic to livestock in South Africa. A chronological account of the history of krimpsiekte research is provided.


Cotyledonosis; History; Krimpsiekte; Nenta


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