Original Research

The efficacy of a slow-release albendazole capsule against Haemonchus contortus with known resistance to albendazole

Alan D. Fisher, Sybrand J. van Sittert
Journal of the South African Veterinary Association | Vol 84, No 1 | a1000 | DOI: https://doi.org/10.4102/jsava.v84i1.1000 | © 2013 Alan D. Fisher, Sybrand J. van Sittert | This work is licensed under CC Attribution 4.0
Submitted: 03 February 2013 | Published: 03 December 2013

About the author(s)

Alan D. Fisher, Eastern Cape Department of Rural Development and Agrarian Reform, Provincial Veterinary Laboratory, Queenstown, South Africa
Sybrand J. van Sittert, MSD Malelane Research Unit, Malelane, South Africa

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Controlled-release albendazole capsules (CRCs) are currently registered for use in Australia and New Zealand as anthelmintic treatment in sheep. However, reports on the efficacy of such products on resistant parasite populations are sometimes controversial. This is the first study to report on the efficacy of such products under South African field conditions in sheep harbouring a population of Haemonchus contortus with known multiple anthelmintic resistance, including to albendazole. Treatment groups were comprised of CRC-treated and single dose albendazole-treated sheep, as well as negative controls. Groups were compared by using faecal egg count reduction tests, FAMACHA© anaemia scoring, conception rates and comparative weight gains over three and a half months. Based on a comparison of faecal egg counts, no advantage could be found using CRCs. Moreover, the use of the product actually decreased weight gain when compared with the control group animals.


Haemonchus contortus; resistance; Controlled Release Capsules; albendazole; FAMACHA


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Crossref Citations

1. Gene silencing of Dim-1, a member of the disorganized muscle family, in Haemonchus contortus
Amilcar Arenal, Arnielis Díaz, Lew Kan Sprenger, Andreia Buzatti, Maria Angela Machado Fernandes, Jeannie Nascimento dos Santos, Marcelo Molento
Molecular and Biochemical Parasitology  vol: 211  first page: 71  year: 2017  
doi: 10.1016/j.molbiopara.2016.10.004